What did you gain from the experience?
I definitely learned how a lot of laboratory techniques are done and a lot of new information specific to my project that I wasn't... Read More... Jess Genevieve Bailey History of Art How did you first get involved in research on campus?
My first semester at Berkeley I made myself a promise: I would go to two out of my four Professor's office hours each week with substantial questions. New to Berkeley as a transfer student, I knew I had less time than others to create meaningful faculty mentoring relationships. By the end of my first semester I was offered a URAP position which launched my experience in research, including work-based travel to European archives and cultural institutions the following summer. I got involved in research at Berkeley... Read More... See Other Undergraduate Researchers Here Donate to Undergraduate Research University of California Berkeley
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Because orexin-A receptors have been shown to regulate relapse to cocaine seeking, a new study investigated its relation to nicotine by studying rats. By blocking the orexin-A receptor with low doses of the selective orexin antagonist SB-334,867 , nicotine self-administration decreased and also the motivation to seek and obtain the drug. The study showed that blocking of receptors in the insula decreased self-administration , but not blocking of receptors in the adjacent somatosensory cortex . The greatest decrease in self-administration was found when blocking all orexin-A receptors in the brain as a whole. A rationale for this study was the fact that the insula has been implicated in regulating feelings of craving. The insula contains orexin-A receptors. It has been reported that smokers who sustained damage to the insula lost the desire to smoke. 
This section is optional. You can thank those who either helped with the experiments, or made other important contributions, such as discussing the protocol, commenting on the manuscript, or buying you pizza.